PDBe 1u4d

X-ray diffraction
2.1Å resolution

Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated CDC42 kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 291 amino acids
Theoretical weight: 33.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07912 (Residues: 109-395; Coverage: 28%)
Gene names: ACK1, TNK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 81.552Å b: 42.918Å c: 85.149Å
α: 90° β: 112.02° γ: 90°
R-values:
R R work R free
0.205 0.203 0.248
Expression system: Spodoptera frugiperda