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HINCII BOUND TO COGNATE DNA

X-ray diffraction
2.5Å resolution
PDB entry 1tx3 coloured by chain, front view.
PDB entry 1tx3 coloured by chain, side view.
PDB entry 1tx3 coloured by chain, top view.
Source organism: Haemophilus influenzae
Assemblies composition:
hetero hexamer
hetero pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1
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Assembly Name: Type II restriction enzyme HincII and DNA
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Multimeric state: hetero hexamer
Accessible surface area: 38670.32 Å2
Buried surface area: 12621.57 Å2
Dissociation area: 304.67 Å2
Dissociation energy (ΔGdiss): -7.18 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114665
Assembly 2 (preferred)
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Assembly Name: Type II restriction enzyme HincII and DNA
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Multimeric state: hetero pentamer
Accessible surface area: 26011.01 Å2
Buried surface area: 10912.05 Å2
Dissociation area: 299.46 Å2
Dissociation energy (ΔGdiss): -4.26 kcal/mol
Dissociation entropy (TΔSdiss): 10.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114664

Macromolecules

Type II restriction enzyme HincII
Chains: A, B, C, D
Length: 257 amino acids
Theoretical weight: 29.82 KDa
Source organism: Haemophilus influenzae
Expression system: Escherichia coli
UniProt:
  • Canonical: P17743 (Residues: 2-258; Coverage: 100%)
Gene name: hincIIR
Pfam: Restriction endonuclease HincII
InterPro:
CATH: DNA mismatch repair MutH/Restriction endonuclease, type II
SCOP: Restriction endonuclease HincII
Type II restriction enzyme HincII in PDB entry 1tx3, assembly 2, front view.
Type II restriction enzyme HincII in PDB entry 1tx3, assembly 2, side view.
Type II restriction enzyme HincII in PDB entry 1tx3, assembly 2, top view.
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DNA chains E, F, G, H
Name: 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3'
Representative chains: E, F, G, H
Source organism: Haemophilus influenzae [727]
Expression system: Not provided
Length: 13 nucleotides
Theoretical weight: 3.99 KDa
5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3' in PDB entry 1tx3, assembly 2, front view.
5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3' in PDB entry 1tx3, assembly 2, side view.
5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3' in PDB entry 1tx3, assembly 2, top view.
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