Function and Biology

P53 CORE DOMAIN IN COMPLEX WITH DNA

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: apoptotic process
Cellular component: nucleus

Sequence family

Pfam Protein family (Pfam)
PF00870
Domain description: P53 DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 1tsr contains 3 copies of Pfam domain PF00870 (P53 DNA-binding domain) in Cellular tumor antigen p53. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR002117
Domain description: p53 tumour suppressor family
Occurring in:
  1. Cellular tumor antigen p53
IPR011615
Domain description: p53, DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR012346
Domain description: p53/RUNT-type transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53

Structure domain

CATH CATH domain
2.60.40.720
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 1tsr contains 3 copies of CATH domain 2.60.40.720 (Immunoglobulin-like) in Cellular tumor antigen p53. Showing 1 copy in chain C [auth A].
SCOP SCOP annotation
81314
Class: All beta proteins
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 1tsr contains 3 copies of SCOP domain 81314 (p53 DNA-binding domain-like) in Cellular tumor antigen p53. Showing 1 copy in chain C [auth A].