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TERNARY SUBSTRATE COMPLEX OF THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM TRYPANOSOMA CRUZI

Source organism: Trypanosoma cruzi
Biochemical function: guanine phosphoribosyltransferase activity
Biological process: hypoxanthine metabolic process
Cellular component: cytosol

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EC 2.4.2.8: Hypoxanthine phosphoribosyltransferase

Reaction catalysed:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Systematic name:
IMP:diphosphate phospho-D-ribosyltransferase
Alternative Name(s):
  • 6-hydroxypurine phosphoribosyltransferase
  • 6-mercaptopurine phosphoribosyltransferase
  • GMP pyrophosphorylase
  • GPRT
  • Guanine phosphoribosyltransferase
  • Guanine-hypoxanthine phosphoribosyltransferase
  • Guanosine 5'-phosphate pyrophosphorylase
  • Guanosine phosphoribosyltransferase
  • Guanylate pyrophosphorylase
  • Guanylic pyrophosphorylase
  • HGPRTase
  • HPRT
  • Hypoxanthine-guanine phosphoribosyltransferase
  • IMP diphosphorylase
  • IMP pyrophosphorylase
  • IMP-GMP pyrophosphorylase
  • Inosinate pyrophosphorylase
  • Inosine 5'-phosphate pyrophosphorylase
  • Inosinic acid pyrophosphorylase
  • Inosinic pyrophosphorylase
  • Purine-6-thiol phosphoribosyltransferase
  • Transphosphoribosidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00156
Domain description: Phosphoribosyl transferase domain
Occurring in:
  1. Hypoxanthine phosphoribosyltransferase
The deposited structure of PDB entry 1tc2 contains 2 copies of Pfam domain PF00156 (Phosphoribosyl transferase domain) in Hypoxanthine phosphoribosyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000836
Domain description: Phosphoribosyltransferase domain
Occurring in:
  1. Hypoxanthine phosphoribosyltransferase
IPR029057
Domain description: Phosphoribosyltransferase-like
Occurring in:
  1. Hypoxanthine phosphoribosyltransferase
IPR005904
Domain description: Hypoxanthine phosphoribosyl transferase
Occurring in:
  1. Hypoxanthine phosphoribosyltransferase

Structure domain

CATH CATH domain
3.40.50.2020
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Hypoxanthine phosphoribosyltransferase
The deposited structure of PDB entry 1tc2 contains 2 copies of CATH domain 3.40.50.2020 (Rossmann fold) in Hypoxanthine phosphoribosyltransferase. Showing 1 copy in chain B.
SCOP SCOP annotation
53272
Class: Alpha and beta proteins (a/b)
Fold: PRTase-like
Superfamily: PRTase-like
Occurring in:
  1. Hypoxanthine phosphoribosyltransferase
The deposited structure of PDB entry 1tc2 contains 2 copies of SCOP domain 53272 (Phosphoribosyltransferases (PRTases)) in Hypoxanthine phosphoribosyltransferase. Showing 1 copy in chain B.

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