› › Structure analysis

2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex

X-ray diffraction
2.5Å resolution
PDB entry 1tb6 coloured by chain, front view.
PDB entry 1tb6 coloured by chain, side view.
PDB entry 1tb6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: alpha-thrombin complex and Antithrombin-III
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 31277.92 Å2
Buried surface area: 16904.32 Å2
Dissociation area: 1,683.62 Å2
Dissociation energy (ΔGdiss): 16.12 kcal/mol
Dissociation entropy (TΔSdiss): 11.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133063

Macromolecules

Thrombin light chain
Chain: L
Length: 49 amino acids
Theoretical weight: 5.64 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 315-363; Coverage: 8%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
CATH: Thrombin light chain domain
SCOP: Eukaryotic proteases
Thrombin light chain in PDB entry 1tb6, assembly 1, front view.
Thrombin light chain in PDB entry 1tb6, assembly 1, side view.
Thrombin light chain in PDB entry 1tb6, assembly 1, top view.
Molecule details ›

Search similar proteins

Thrombin heavy chain
Chain: H
Length: 259 amino acids
Theoretical weight: 29.76 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Thrombin heavy chain in PDB entry 1tb6, assembly 1, front view.
Thrombin heavy chain in PDB entry 1tb6, assembly 1, side view.
Thrombin heavy chain in PDB entry 1tb6, assembly 1, top view.
Molecule details ›

Search similar proteins

Antithrombin-III
Chain: I
Length: 432 amino acids
Theoretical weight: 49.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Pfam: Serpin (serine protease inhibitor)
InterPro:
CATH:
SCOP: Serpins
Antithrombin-III in PDB entry 1tb6, assembly 1, front view.
Antithrombin-III in PDB entry 1tb6, assembly 1, side view.
Antithrombin-III in PDB entry 1tb6, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links