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Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor

X-ray diffraction
2.47Å resolution
PDB entry 1t7d coloured by chain, front view.
PDB entry 1t7d coloured by chain, side view.
PDB entry 1t7d coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Signal peptidase I and peptide
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Multimeric state: hetero dimer
Accessible surface area: 11144.13 Å2
Buried surface area: 835.36 Å2
Dissociation area: 417.68 Å2
Dissociation energy (ΔGdiss): 2.25 kcal/mol
Dissociation entropy (TΔSdiss): 6.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133585
Assembly 2
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Assembly Name: Signal peptidase I and peptide
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Multimeric state: hetero dimer
Accessible surface area: 10515.19 Å2
Buried surface area: 862.2 Å2
Dissociation area: 431.1 Å2
Dissociation energy (ΔGdiss): 1.93 kcal/mol
Dissociation entropy (TΔSdiss): 6.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133585

Macromolecules

Signal peptidase I
Chains: A, B
Length: 250 amino acids
Theoretical weight: 28.08 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00803 (Residues: 75-324; Coverage: 77%)
Gene names: JW2552, b2568, lepB
Pfam: Signal peptidase, peptidase S26
InterPro:
CATH:
SCOP: Type 1 signal peptidase
Signal peptidase I in PDB entry 1t7d, assembly 1, front view.
Signal peptidase I in PDB entry 1t7d, assembly 1, side view.
Signal peptidase I in PDB entry 1t7d, assembly 1, top view.
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ARYLOMYCIN A2
Chains: C, D
Length: 6 amino acids
Theoretical weight: 645 Da
Source organism: Streptomyces sp.
ARYLOMYCIN A2 in PDB entry 1t7d, assembly 1, front view.
ARYLOMYCIN A2 in PDB entry 1t7d, assembly 1, side view.
ARYLOMYCIN A2 in PDB entry 1t7d, assembly 1, top view.
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