PDBe 1t73

X-ray diffraction
2.2Å resolution

Crystal structure of the androgen receptor ligand binding domain in complex with a FxxFF motif


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.88 KDa
Source organism: Pan troglodytes
Expression system: Escherichia coli
  • Canonical: O97775 (Residues: 654-911; Coverage: 28%)
Gene names: AR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
FxxFF motif peptide Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.18 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 54.323Å b: 66.592Å c: 70.223Å
α: 90° β: 90° γ: 90°
R R work R free
0.2 0.2 0.245
Expression systems:
  • Escherichia coli
  • Not provided