PDBe 1t45

X-ray diffraction
1.9Å resolution

STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10721 (Residues: 547-935; Coverage: 35%)
Gene names: KIT, SCFR
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 44.414Å b: 77.23Å c: 94.574Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.222
Expression system: Spodoptera frugiperda