› 1t45

X-ray diffraction
1.9Å resolution

STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE

Released:
DOI: 10.2210/pdb1t45/pdb
PDB entry 1t45 coloured by chain, front view.
PDB entry 1t45 coloured by chain, side view.
PDB entry 1t45 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
Mol CD, Dougan DR, Schneider TR, Skene RJ, Kraus ML, Scheibe DN, Snell GP, Zou H, Sang BC, Wilson KP
J Biol Chem 279 31655-63 (2004)
PMID: 15123710

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10721 (Residues: 547-935; Coverage: 35%)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 44.414Å b: 77.23Å c: 94.574Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.222
Expression system: Spodoptera frugiperda

Quick links

Citations

85 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
84 more

33 mentions without citation

Novel approaches to treating advanced systemic mastocytosis.
Gilreath et al. (2019)
32 more