PDBe 1t3l

X-ray diffraction
2.2Å resolution

Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core in Complex with Alpha1 Interaction Domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1S Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 2.18 KDa
Source organism: Oryctolagus cuniculus
Expression system: Not provided
UniProt:
  • Canonical: P07293 (Residues: 357-374; Coverage: 1%)
Gene names: CACH1, CACNA1S, CACNL1A3
Voltage-dependent L-type calcium channel subunit beta-2 Chain: A
Molecule details ›
Chain: A
Length: 337 amino acids
Theoretical weight: 38.34 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54288 (Residues: 51-448; Coverage: 53%)
  • Best match: P54288-3 (Residues: 51-410)
Gene names: CACNB2, CACNLB2
Sequence domains: Guanylate kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 72.775Å b: 168.262Å c: 34.233Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.221 0.282
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)