PDBe 1t0h

X-ray diffraction
1.97Å resolution

Crystal structure of the Rattus norvegicus voltage gated calcium channel beta subunit isoform 2a

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Voltage-dependent L-type calcium channel subunit beta-2 Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.14 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VGC3 (Residues: 68-196; Coverage: 20%)
Gene names: Cacnb2, Cacnlb2
Sequence domains: Voltage gated calcium channel subunit beta domain 4Aa N terminal
Structure domains: SH3 Domains
Voltage-dependent L-type calcium channel subunit beta-2 Chain: B
Molecule details ›
Chain: B
Length: 224 amino acids
Theoretical weight: 25.6 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VGC3 (Residues: 254-476; Coverage: 34%)
Gene names: Cacnb2, Cacnlb2
Sequence domains: Guanylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P1
Unit cell:
a: 36.176Å b: 45.26Å c: 58.701Å
α: 107.34° β: 95.75° γ: 97°
R-values:
R R work R free
0.187 0.185 0.213
Expression system: Escherichia coli