PDBe 1t08

X-ray diffraction
2.1Å resolution

Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 519 amino acids
Theoretical weight: 56.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P35222 (Residues: 146-664; Coverage: 67%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Adenomatous polyposis coli protein Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P25054 (Residues: 1484-1498; Coverage: 1%)
Gene names: APC, DP2.5
Beta-catenin-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 46 amino acids
Theoretical weight: 5.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NSA3 (Residues: 8-53; Coverage: 57%)
Gene names: CTNNBIP1, ICAT
Structure domains: beta-catenin-interacting protein ICAT, Chain B, ?????domain1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1, null
Spacegroup: P21212
Unit cell:
a: 96.472Å b: 96.712Å c: 86.395Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.204 0.241
Expression system: Escherichia coli BL21