Function and Biology

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases

Source organisms:
Biochemical function: zinc ion binding
Biological process: not assigned
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02146
Domain description: Sir2 family
Occurring in:
  1. NAD-dependent protein deacetylase HST2
1 copy of Pfam domain PF02146 (Sir2 family) in NAD-dependent protein deacetylase HST2 in PDB 1szd.

InterPro InterPro annotations
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. NAD-dependent protein deacetylase HST2
IPR003000
Domain description: Sirtuin family
Occurring in:
  1. NAD-dependent protein deacetylase HST2
IPR026590
Domain description: Sirtuin family, catalytic core domain
Occurring in:
  1. NAD-dependent protein deacetylase HST2
IPR017328
Domain description: Sirtuin, class I
Occurring in:
  1. NAD-dependent protein deacetylase HST2

Structure domains

CATH CATH domains
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. NAD-dependent protein deacetylase HST2
1 copy of CATH domain 3.40.50.1220 (Rossmann fold) in NAD-dependent protein deacetylase HST2 in PDB 1szd.
3.30.1600.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SIR2/SIRT2 'Small Domain'
Homology: SIR2/SIRT2 'Small Domain'
Occurring in:
  1. NAD-dependent protein deacetylase HST2
1 copy of CATH domain 3.30.1600.10 (SIR2/SIRT2 'Small Domain') in NAD-dependent protein deacetylase HST2 in PDB 1szd.
SCOP SCOP annotation
63984
Class: Alpha and beta proteins (a/b)
Fold: DHS-like NAD/FAD-binding domain
Superfamily: DHS-like NAD/FAD-binding domain
Occurring in:
  1. NAD-dependent protein deacetylase HST2
1 copy of SCOP domain 63984 (Sir2 family of transcriptional regulators) in NAD-dependent protein deacetylase HST2 in PDB 1szd.