Function and Biology

PHOSPHO-ADENYLYL-SULFATE REDUCTASE

Source organism: Escherichia coli
Biochemical function: catalytic activity
Biological process: oxidation-reduction process
Cellular component: not assigned

EC 1.8.4.8: Phosphoadenylyl-sulfate reductase (thioredoxin)

Reaction catalysed:
Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
Comments:
  • Specific for PAPS.
  • The enzyme from Escherichia coli will use thioredoxins from other species.
  • Formerly EC 1.8.99.4.
Systematic name:
Adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
Alternative Name(s):
  • 3'-phosphoadenylylsulfate reductase
  • PAPS reductase
  • PAPS reductase, thioredoxin-dependent
  • Adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
  • Phosphoadenosine-phosphosulfate reductase
  • Thioredoxin:3'-phospho-adenylylsulfate reductase
  • Thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase
  • PAdoPS reductase
  • PAPS sulfotransferase

Sequence family

InterPro InterPro annotations
IPR002500
Domain description: Phosphoadenosine phosphosulphate reductase
Occurring in:
  1. Phosphoadenosine phosphosulfate reductase
IPR004511
Domain description: Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase
Occurring in:
  1. Phosphoadenosine phosphosulfate reductase
IPR011800
Domain description: Phosphoadenosine phosphosulphate reductase CysH
Occurring in:
  1. Phosphoadenosine phosphosulfate reductase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Phosphoadenosine phosphosulfate reductase

Structure domain

CATH CATH domain
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. Phosphoadenosine phosphosulfate reductase
1 copy of CATH domain 3.40.50.620 (Rossmann fold) in Phosphoadenosine phosphosulfate reductase in PDB 1sur.
SCOP SCOP annotation
52410
Class: Alpha and beta proteins (a/b)
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Adenine nucleotide alpha hydrolases-like
Occurring in:
  1. Phosphoadenosine phosphosulfate reductase
1 copy of SCOP domain 52410 (PAPS reductase-like) in Phosphoadenosine phosphosulfate reductase in PDB 1sur.