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X-ray structure of human proMMP-1: New insights into collagenase action

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: cellular response to UV-A
Cellular component: extracellular matrix

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EC 3.4.24.7: Interstitial collagenase

Reaction catalysed:
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
Systematic name:
-
Alternative Name(s):
  • Matrix metalloproteinase 1
  • Vertebrate collagenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00045
Domain description: Hemopexin
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 8 copies of Pfam domain PF00045 (Hemopexin) in Interstitial collagenase. Showing 4 copies in chain B.

PF00413
Domain description: Matrixin
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of Pfam domain PF00413 (Matrixin) in Interstitial collagenase. Showing 1 copy in chain B.

PF01471
Domain description: Putative peptidoglycan binding domain
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of Pfam domain PF01471 (Putative peptidoglycan binding domain) in Interstitial collagenase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR018487
Domain description: Hemopexin-like repeats
Occurring in:
  1. Interstitial collagenase
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Interstitial collagenase
IPR036375
Domain description: Hemopexin-like domain superfamily
Occurring in:
  1. Interstitial collagenase
IPR018486
Domain description: Hemopexin, conserved site
Occurring in:
  1. Interstitial collagenase
IPR000585
Domain description: Hemopexin-like domain
Occurring in:
  1. Interstitial collagenase
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Interstitial collagenase
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Interstitial collagenase
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Interstitial collagenase
IPR021158
Domain description: Peptidase M10A, cysteine switch, zinc binding site
Occurring in:
  1. Interstitial collagenase
IPR002477
Domain description: Peptidoglycan binding-like
Occurring in:
  1. Interstitial collagenase
IPR036365
Domain description: PGBD-like superfamily
Occurring in:
  1. Interstitial collagenase
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Interstitial collagenase

Structure domains

CATH CATH domains
2.110.10.10
Class: Mainly Beta
Architecture: 4 Propeller
Topology: Hemopexin
Homology: Hemopexin-like domain
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of CATH domain 2.110.10.10 (Hemopexin) in Interstitial collagenase. Showing 1 copy in chain B.
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Interstitial collagenase. Showing 1 copy in chain B.
SCOP SCOP annotations
50924
Class: All beta proteins
Fold: 4-bladed beta-propeller
Superfamily: Hemopexin-like domain
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of SCOP domain 50924 (Hemopexin-like domain) in Interstitial collagenase. Showing 1 copy in chain B.
55528
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of SCOP domain 55528 (Matrix metalloproteases, catalytic domain) in Interstitial collagenase. Showing 1 copy in chain B.
63427
Class: All alpha proteins
Fold: PGBD-like
Superfamily: PGBD-like
Occurring in:
  1. Interstitial collagenase
The deposited structure of PDB entry 1su3 contains 2 copies of SCOP domain 63427 (MMP N-terminal domain) in Interstitial collagenase. Showing 1 copy in chain B.

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