PDBe 1ssu

Solution NMR

Structural and biochemical evidence for disulfide bond heterogeneity in active forms of the somatomedin B domain of human vitronectin

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Somatomedin-B Chain: A
Molecule details ›
Chain: A
Length: 51 amino acids
Theoretical weight: 5.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04004 (Residues: 20-70; Coverage: 11%)
Gene name: VTN
Sequence domains: Somatomedin B domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 58%
Refinement method: torsion angle dynamics in DYANA followed by simulated annealing and energy minimization in AMBER
Chemical shifts: BMR6160  
Expression system: Escherichia coli