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Substituted 2-Naphthamidine Inhibitors of Urokinase

X-ray diffraction
1.84Å resolution
PDB entry 1sqo coloured by chain, front view.
PDB entry 1sqo coloured by chain, side view.
PDB entry 1sqo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Urokinase-type plasminogen activator short chain A
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-133249

Macromolecules

Urokinase-type plasminogen activator chain B
Chain: A
Length: 245 amino acids
Theoretical weight: 27.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00749 (Residues: 179-423; Coverage: 60%)
Gene name: PLAU
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Urokinase-type plasminogen activator chain B in PDB entry 1sqo, assembly 1, front view.
Urokinase-type plasminogen activator chain B in PDB entry 1sqo, assembly 1, side view.
Urokinase-type plasminogen activator chain B in PDB entry 1sqo, assembly 1, top view.
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