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Progesterone Receptor Ligand Binding Domain with bound Norethindrone

X-ray diffraction
1.451Å resolution
PDB entry 1sqn coloured by chain, front view.
PDB entry 1sqn coloured by chain, side view.
PDB entry 1sqn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Progesterone receptor
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Multimeric state: monomeric
Accessible surface area: 11952.48 Å2
Buried surface area: 689.9 Å2
Dissociation area: 344.95 Å2
Dissociation energy (ΔGdiss): -1.64 kcal/mol
Dissociation entropy (TΔSdiss): 3.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139037
Assembly 2
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Assembly Name: Progesterone receptor
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Multimeric state: monomeric
Accessible surface area: 11681.82 Å2
Buried surface area: 685.5 Å2
Dissociation area: 342.75 Å2
Dissociation energy (ΔGdiss): -1.79 kcal/mol
Dissociation entropy (TΔSdiss): 3.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139037

Macromolecules

Progesterone receptor
Chains: A, B
Length: 261 amino acids
Theoretical weight: 30.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 673-933; Coverage: 28%)
Gene names: NR3C3, PGR
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Progesterone receptor in PDB entry 1sqn, assembly 1, front view.
Progesterone receptor in PDB entry 1sqn, assembly 1, side view.
Progesterone receptor in PDB entry 1sqn, assembly 1, top view.
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