PDBe 1sqn

X-ray diffraction
1.45Å resolution

Progesterone Receptor Ligand Binding Domain with bound Norethindrone

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 261 amino acids
Theoretical weight: 30.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 673-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 57.753Å b: 64.142Å c: 70.138Å
α: 90° β: 95.84° γ: 90°
R-values:
R R work R free
0.188 0.186 0.216
Expression system: Escherichia coli