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TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN).

Source organism: Tetronarce californica
Biochemical function: carboxylic ester hydrolase activity
Biological process: choline metabolic process
Cellular component: side of membrane

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EC 3.1.1.7: Acetylcholinesterase

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Systematic name:
Acetylcholine acetylhydrolase
Alternative Name(s):
  • AcCholE
  • Acetyl.beta-methylcholinesterase
  • Acetylcholine hydrolase
  • Acetylthiocholinesterase
  • Choline esterase I
  • Cholinesterase
  • True cholinesterase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 1som contains 1 copy of Pfam domain PF00135 (Carboxylesterase family) in Acetylcholinesterase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000997
Domain description: Cholinesterase
Occurring in:
  1. Acetylcholinesterase
IPR000908
Domain description: Acetylcholinesterase, fish/snake
Occurring in:
  1. Acetylcholinesterase
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Acetylcholinesterase
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Acetylcholinesterase
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Acetylcholinesterase
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Acetylcholinesterase

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 1som contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Acetylcholinesterase. Showing 1 copy in chain A.
SCOP SCOP annotation
53475
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 1som contains 1 copy of SCOP domain 53475 (Acetylcholinesterase-like) in Acetylcholinesterase. Showing 1 copy in chain A.

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