PDBe 1smr

X-ray diffraction
2Å resolution

The 3-d structure of mouse submaxillary renin complexed with a decapeptide inhibitor ch-66 based on the 4-16 fragment of rat angiotensinogen

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
homo tetramer
monomeric
hetero octamer
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Renin-2 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 335 amino acids
Theoretical weight: 36.53 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P00796 (Residues: 67-401; Coverage: 89%)
Gene names: Ren-2, Ren2
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases
Angiotensin 1-9 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 9 amino acids
Theoretical weight: 1.26 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P01015 (Residues: 30-38; Coverage: 2%)
Gene names: Agt, Serpina8

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 78.34Å b: 117.76Å c: 85.88Å
α: 90° β: 101.18° γ: 90°
R-values:
R R work R free
0.18 not available not available
Expression system: Not provided