PDBe 1skj

X-ray diffraction
2Å resolution

COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase transforming protein Src Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.91 KDa
Source organism: Rous sarcoma virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00524 (Residues: 144-249, 250-252; Coverage: 21%)
Gene name: V-SRC
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P61
Unit cell:
a: 74.4Å b: 74.4Å c: 38.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.2 0.275
Expression system: Escherichia coli