› › Structure analysis

Crystal structure of the anticoagulant slow form of thrombin

X-ray diffraction
2.3Å resolution
PDB entry 1sgi coloured by chain, front view.
PDB entry 1sgi coloured by chain, side view.
PDB entry 1sgi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: alpha-thrombin complex
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 13017.76 Å2
Buried surface area: 2512.81 Å2
Dissociation area: 1,159.17 Å2
Dissociation energy (ΔGdiss): 8.3 kcal/mol
Dissociation entropy (TΔSdiss): 10.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133055
Complex Portal ID: CPX-6222
Assembly 2
Download    3D Visualisation
Assembly Name: alpha-thrombin complex
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 12655.68 Å2
Buried surface area: 2353.23 Å2
Dissociation area: 1,079.05 Å2
Dissociation energy (ΔGdiss): 9.63 kcal/mol
Dissociation entropy (TΔSdiss): 9.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133055
Complex Portal ID: CPX-6222

Macromolecules

Thrombin light chain
Chains: A, D
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Thrombin light chain in PDB entry 1sgi, assembly 1, front view.
Thrombin light chain in PDB entry 1sgi, assembly 1, side view.
Thrombin light chain in PDB entry 1sgi, assembly 1, top view.
Molecule details ›

Search similar proteins

Thrombin heavy chain
Chains: B, E
Length: 259 amino acids
Theoretical weight: 29.69 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Thrombin heavy chain in PDB entry 1sgi, assembly 1, front view.
Thrombin heavy chain in PDB entry 1sgi, assembly 1, side view.
Thrombin heavy chain in PDB entry 1sgi, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links