PDBe 1sg4

X-ray diffraction
1.3Å resolution

Crystal structure of human mitochondrial delta3-delta2-enoyl-CoA isomerase

Released:

Function and Biology Details

Reaction catalysed:
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-CoA delta isomerase 1, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 260 amino acids
Theoretical weight: 28.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42126 (Residues: 43-302; Coverage: 86%)
Gene names: DCI, ECI1
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains: 2-enoyl-CoA Hydratase; Chain A, domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: C2
Unit cell:
a: 100.984Å b: 78.288Å c: 113.209Å
α: 90° β: 116.39° γ: 90°
R-values:
R R work R free
0.157 0.157 0.202
Expression system: Escherichia coli