PDBe 1seb

X-ray diffraction
2.7Å resolution

COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Enterotoxin type B Chains: D, H
Molecule details ›
Chains: D, H
Length: 234 amino acids
Theoretical weight: 27.79 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: P01552 (Residues: 29-262; Coverage: 98%)
Gene name: entB
Sequence domains:
Structure domains:
ENDOGENOUS PEPTIDE MODEL, POLY-ALA Chains: C, G
Molecule details ›
Chains: C, G
Length: 13 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
HLA class II histocompatibility antigen, DR alpha chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-1 beta chain Chains: B, F
Molecule details ›
Chains: B, F
Length: 192 amino acids
Theoretical weight: 22.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04229 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 95Å b: 114.7Å c: 149.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.257 0.327
Expression system: Homo sapiens