PDBe 1s9v

X-ray diffraction
2.22Å resolution

Crystal structure of HLA-DQ2 complexed with deamidated gliadin peptide

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.
Proc. Natl. Acad. Sci. U.S.A. 101 4175-9 (2004)
PMID: 15020763

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
alpha-I gliadin Chains: C, F
Molecule details ›
Chains: C, F
Length: 11 amino acids
Theoretical weight: 1.33 KDa
HLA class II histocompatibility antigen, DQ beta 1 chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 198 amino acids
Theoretical weight: 23.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01920 (Residues: 33-230; Coverage: 87%)
Gene names: HLA-DQB, HLA-DQB1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DQ alpha 1 chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 193 amino acids
Theoretical weight: 21.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01909 (Residues: 24-216; Coverage: 84%)
Gene name: HLA-DQA1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 91.11Å b: 93.75Å c: 102.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.283
Expression system: Spodoptera frugiperda