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crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with diethylstilbestrol

X-ray diffraction
2.13Å resolution
PDB entry 1s9p coloured by chain, front view.
PDB entry 1s9p coloured by chain, side view.
PDB entry 1s9p coloured by chain, top view.
Source organism: Mus musculus
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen-related receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 20252.87 Å2
Buried surface area: 3974.51 Å2
Dissociation area: 1,298.82 Å2
Dissociation energy (ΔGdiss): 0.8 kcal/mol
Dissociation entropy (TΔSdiss): 12.98 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158637
Assembly 2
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Assembly Name: Estrogen-related receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 20282.1 Å2
Buried surface area: 3907.49 Å2
Dissociation area: 1,263.72 Å2
Dissociation energy (ΔGdiss): -0.53 kcal/mol
Dissociation entropy (TΔSdiss): 13.01 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158637
Assembly 3
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Assembly Name: Estrogen-related receptor gamma
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Multimeric state: homo tetramer
Accessible surface area: 38209.01 Å2
Buried surface area: 10193.34 Å2
Dissociation area: 3,718.96 Å2
Dissociation energy (ΔGdiss): 5.61 kcal/mol
Dissociation entropy (TΔSdiss): 39.69 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158638
Assembly 4
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Assembly Name: Estrogen-related receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 21127.56 Å2
Buried surface area: 3001.75 Å2
Dissociation area: 808.43 Å2
Dissociation energy (ΔGdiss): 5.06 kcal/mol
Dissociation entropy (TΔSdiss): 12.73 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158637
Assembly 5
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Assembly Name: Estrogen-related receptor gamma
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Multimeric state: homo dimer
Accessible surface area: 21320.48 Å2
Buried surface area: 2963.37 Å2
Dissociation area: 795.5 Å2
Dissociation energy (ΔGdiss): 2.12 kcal/mol
Dissociation entropy (TΔSdiss): 12.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158637

Macromolecules

Estrogen-related receptor gamma
Chains: A, B, C, D
Length: 227 amino acids
Theoretical weight: 25.79 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62509 (Residues: 232-458; Coverage: 50%)
Gene names: Err3, Esrrg, Kiaa0832, Nr3b3
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Estrogen-related receptor gamma in PDB entry 1s9p, assembly 1, front view.
Estrogen-related receptor gamma in PDB entry 1s9p, assembly 1, side view.
Estrogen-related receptor gamma in PDB entry 1s9p, assembly 1, top view.
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