› 1s47

X-ray diffraction
2.5Å resolution

Crystal structure analysis of the DNA quadruplex d(TGGGGT)S2

Released:
DOI: 10.2210/pdb1s47/pdb
PDB entry 1s47 coloured by chain, front view.
PDB entry 1s47 coloured by chain, side view.
PDB entry 1s47 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions.
Cáceres C, Wright G, Gouyette C, Parkinson G, Subirana JA
Nucleic Acids Res 32 1097-102 (2004)
PMID: 14960719

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114572 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*GP*GP*GP*GP*T)-3' Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NA 7 x NA
Ligand TL 6 x TL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 28.319Å b: 56.341Å c: 51.746Å
α: 90° β: 99.17° γ: 90°
R-values:
R R work R free
0.224 0.224 0.311
Expression system: Not provided

Quick links

Citations

8 review citations

The application of DNA and RNA G-quadruplexes to therapeutic medicines.
Collie et al. (2011)
7 more

3 mentions without citation

Non-G Base Tetrads.
Escaja et al. (2022)
2 more