PDBe 1rzg

X-ray diffraction
2Å resolution

Crystal structure of Human anti-HIV-1 GP120 reactive antibody 412d

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab 412d heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 214 amino acids
Theoretical weight: 23.48 KDa
Source organism: Homo sapiens
Expression system: Human gammaherpesvirus 4
Structure domains: Immunoglobulins
Fab 412d light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 231 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Human gammaherpesvirus 4
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 63.088Å b: 89.313Å c: 85.863Å
α: 90° β: 110.31° γ: 90°
R-values:
R R work R free
0.201 0.201 0.251
Expression system: Human gammaherpesvirus 4