PDBe 1ry7

X-ray diffraction
3.2Å resolution

Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor 1 Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 17.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 1-155; Coverage: 100%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Fibroblast growth factor receptor 3 Chain: B
Molecule details ›
Chain: B
Length: 334 amino acids
Theoretical weight: 36.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22607 (Residues: 33-365; Coverage: 43%)
Gene names: FGFR3, JTK4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 104.223Å b: 64.748Å c: 99.932Å
α: 90° β: 94.67° γ: 90°
R-values:
R R work R free
0.277 0.277 0.341
Expression system: Escherichia coli