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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES

X-ray diffraction
2.2Å resolution
PDB entry 1rth coloured by chain, front view.
PDB entry 1rth coloured by chain, side view.
PDB entry 1rth coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: hetero dimer
Accessible surface area: 47361.17 Å2
Buried surface area: 5772.11 Å2
Dissociation area: 2,560.57 Å2
Dissociation energy (ΔGdiss): 25.17 kcal/mol
Dissociation entropy (TΔSdiss): 15.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138005

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 560 amino acids
Theoretical weight: 64.59 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 588-1147; Coverage: 39%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
SCOP:
Reverse transcriptase/ribonuclease H in PDB entry 1rth, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 1rth, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 1rth, assembly 1, top view.
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p51 RT
Chain: B
Length: 440 amino acids
Theoretical weight: 51.4 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 588-1027; Coverage: 31%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
SCOP: Reverse transcriptase
p51 RT in PDB entry 1rth, assembly 1, front view.
p51 RT in PDB entry 1rth, assembly 1, side view.
p51 RT in PDB entry 1rth, assembly 1, top view.
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