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X-ray crystal structure of TDP-vancosaminyltransferase GtfD as a complex with TDP and the natural substrate, desvancosaminyl vancomycin.

Source organism: Amycolatopsis orientalis
Biochemical function: enzyme binding
Biological process: cellular glucuronidation
Cellular component: not assigned

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EC 2.4.1.322: Devancosaminyl-vancomycin vancosaminetransferase

Reaction catalysed:
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin
Systematic name:
dTDP-beta-L-vancomycin:devancosaminyl-vancomycin beta-L-vancosaminetransferase
Alternative Name(s):
  • Desvancosaminyl-vancomycin vancosaminetransferase
  • Devancosamine-vancomycin TDP-vancosaminyltransferase
  • GtfD

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06722
Domain description: Erythromycin biosynthesis protein CIII-like, C-terminal domain
Occurring in:
  1. Devancosaminyl-vancomycin vancosaminetransferase
The deposited structure of PDB entry 1rrv contains 2 copies of Pfam domain PF06722 (Erythromycin biosynthesis protein CIII-like, C-terminal domain) in Devancosaminyl-vancomycin vancosaminetransferase. Showing 1 copy in chain A.

PF03033
Domain description: Glycosyltransferase family 28 N-terminal domain
Occurring in:
  1. Devancosaminyl-vancomycin vancosaminetransferase
The deposited structure of PDB entry 1rrv contains 2 copies of Pfam domain PF03033 (Glycosyltransferase family 28 N-terminal domain) in Devancosaminyl-vancomycin vancosaminetransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002213
Domain description: UDP-glucuronosyl/UDP-glucosyltransferase
Occurring in:
  1. Devancosaminyl-vancomycin vancosaminetransferase
IPR004276
Domain description: Glycosyltransferase family 28, N-terminal domain
Occurring in:
  1. Devancosaminyl-vancomycin vancosaminetransferase

Structure domain

CATH CATH domain
3.40.50.2000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glycogen Phosphorylase B;
Occurring in:
  1. Devancosaminyl-vancomycin vancosaminetransferase
The deposited structure of PDB entry 1rrv contains 4 copies of CATH domain 3.40.50.2000 (Rossmann fold) in Devancosaminyl-vancomycin vancosaminetransferase. Showing 2 copies in chain A.
SCOP SCOP annotation
64178
Class: Alpha and beta proteins (a/b)
Fold: UDP-Glycosyltransferase/glycogen phosphorylase
Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase
Occurring in:
  1. Devancosaminyl-vancomycin vancosaminetransferase
The deposited structure of PDB entry 1rrv contains 2 copies of SCOP domain 64178 (Gtf glycosyltransferase) in Devancosaminyl-vancomycin vancosaminetransferase. Showing 1 copy in chain A.

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