Structure analysis

X-ray crystal structure of TDP-vancosaminyltransferase GtfD as a complex with TDP and the natural substrate, desvancosaminyl vancomycin.

X-ray diffraction
2Å resolution
Source organism: Amycolatopsis orientalis
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero dimer
Accessible surface area: 15691.62 Å2
Buried surface area: 3678.09 Å2
Dissociation area: 971.09 Å2
Dissociation energy (ΔGdiss): -0.62 kcal/mol
Dissociation entropy (TΔSdiss): 7.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-162437
Assembly 2 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 15416.58 Å2
Buried surface area: 3405.7 Å2
Dissociation area: 953.71 Å2
Dissociation energy (ΔGdiss): -1.8 kcal/mol
Dissociation entropy (TΔSdiss): 7.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-162437

Macromolecules

Chains: A, B
Length: 416 amino acids
Theoretical weight: 43.91 KDa
Source organism: Amycolatopsis orientalis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9AFC7 (Residues: 1-408; Coverage: 100%)
Gene name: gtfD
Pfam:
InterPro:
CATH: Glycogen Phosphorylase B;
SCOP: Gtf glycosyltransferase

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