PDBe 1rp5

X-ray diffraction
3Å resolution

PBP2x from Streptococcus pneumoniae strain 5259 with reduced susceptibility to beta-lactam antibiotics

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Penicillin-binding protein 2x Chains: A, B
Molecule details ›
Chains: A, B
Length: 702 amino acids
Theoretical weight: 76.91 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: P14677 (Residues: 49-750; Coverage: 94%)
Gene names: SP_0336, pbpX
Sequence domains:
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P4222
Unit cell:
a: 194.989Å b: 194.989Å c: 154.245Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.231 0.256
Expression system: Escherichia coli