PDBe 1rne

X-ray diffraction
2.4Å resolution

THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 90.9Å b: 90.9Å c: 109.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 not available not available
Expression system: Not provided