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Human vinculin head (1-258) in complex with human vinculin tail (879-1066)

X-ray diffraction
2.35Å resolution
PDB entry 1rke coloured by chain, front view.
PDB entry 1rke coloured by chain, side view.
PDB entry 1rke coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vinculin
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Multimeric state: hetero dimer
Accessible surface area: 21239.91 Å2
Buried surface area: 2618.68 Å2
Dissociation area: 1,309.34 Å2
Dissociation energy (ΔGdiss): 7.43 kcal/mol
Dissociation entropy (TΔSdiss): 12.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148318

Macromolecules

Vinculin
Chain: A
Length: 262 amino acids
Theoretical weight: 29.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18206 (Residues: 1-258; Coverage: 23%)
Gene name: VCL
Pfam: Vinculin family
InterPro:
CATH: Alpha-catenin/vinculin-like
SCOP: alpha-catenin/vinculin
Vinculin in PDB entry 1rke, assembly 1, front view.
Vinculin in PDB entry 1rke, assembly 1, side view.
Vinculin in PDB entry 1rke, assembly 1, top view.
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Vinculin
Chain: B
Length: 185 amino acids
Theoretical weight: 20.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18206 (Residues: 947-1134; Coverage: 16%)
Gene name: VCL
Pfam: Vinculin family
InterPro:
CATH: Alpha-catenin/vinculin-like
SCOP: alpha-catenin/vinculin
Vinculin in PDB entry 1rke, assembly 1, front view.
Vinculin in PDB entry 1rke, assembly 1, side view.
Vinculin in PDB entry 1rke, assembly 1, top view.
Molecule details ›

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