PDBe 1rdt

X-ray diffraction
2.4Å resolution

Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 2.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 676-700; Coverage: 2%)
Gene names: BHLHE74, NCOA1, SRC1
CREB-binding protein Chain: E
Molecule details ›
Chain: E
Length: 23 amino acids
Theoretical weight: 2.37 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92793 (Residues: 58-80; Coverage: 1%)
Gene names: CBP, CREBBP
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 225-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Peroxisome proliferator-activated receptor gamma Chain: D
Molecule details ›
Chain: D
Length: 284 amino acids
Theoretical weight: 32.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 49.69Å b: 54.58Å c: 211.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.259
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)