PDBe 1r4f

X-ray diffraction
2.3Å resolution

Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma vivax: Trp260Ala Mutant In Complex With 3-Deaza-Adenosine

Released:

Function and Biology Details

Reaction catalysed:
A purine nucleoside + H(2)O = D-ribose + a purine base. 
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IAG-nucleoside hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 37.6 KDa
Source organism: Trypanosoma vivax
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GPQ4 (Residues: 2-327; Coverage: 100%)
Sequence domains: Inosine-uridine preferring nucleoside hydrolase
Structure domains: Inosine-uridine Nucleoside N-ribohydrolase, chain A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 51.996Å b: 74.865Å c: 81.369Å
α: 90° β: 102.291° γ: 90°
R-values:
R R work R free
0.208 0.205 0.257
Expression system: Escherichia coli