PDBe 1r20

X-ray diffraction
3Å resolution

Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to the synthetic agonist BYI06830

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ecdysone receptor Chain: D
Molecule details ›
Chain: D
Length: 265 amino acids
Theoretical weight: 30.21 KDa
Source organism: Heliothis virescens
Expression system: Escherichia coli
UniProt:
  • Canonical: O18473 (Residues: 306-342, 343-550; Coverage: 43%)
Gene names: EcR, NR1H1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Gene regulation protein Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.95 KDa
Source organism: Heliothis virescens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7SIF6 (Residues: 3-264; Coverage: 99%)
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P321
Unit cell:
a: 149.429Å b: 149.429Å c: 61.058Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.244 0.289
Expression system: Escherichia coli