Structure analysis

Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads

X-ray diffraction
1.8Å resolution
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly
Assembly 2 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 6500 Å2
Buried surface area: 1600 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): 10 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -48 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero tetramer
Accessible surface area: 6300 Å2
Buried surface area: 1400 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): 9 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -25 kcal/mol
Symmetry number: 1

Macromolecules

Chains: C, D
Length: 7 amino acids
Theoretical weight: 886 Da
Source organism: Synthetic construct
Expression system: Not provided

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Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Best match: O89100 (Residues: 50-147)
Gene names: Gads, Grap2, Grb2l, Grid, Mona

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