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Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP

X-ray diffraction
2.35Å resolution
PDB entry 1r0z coloured by chain, front view.
PDB entry 1r0z coloured by chain, side view.
PDB entry 1r0z coloured by chain, top view.
Source organism: Mus musculus
Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cystic fibrosis transmembrane conductance regulator
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Multimeric state: monomeric
Accessible surface area: 13400.85 Å2
Buried surface area: 946.74 Å2
Dissociation area: 76.85 Å2
Dissociation energy (ΔGdiss): 11.58 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150714
Assembly 2
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Assembly Name: Cystic fibrosis transmembrane conductance regulator
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Multimeric state: monomeric
Accessible surface area: 13240.04 Å2
Buried surface area: 952.23 Å2
Dissociation area: 77.99 Å2
Dissociation energy (ΔGdiss): 11.52 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150714
Assembly 3
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Assembly Name: Cystic fibrosis transmembrane conductance regulator
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Multimeric state: monomeric
Accessible surface area: 13264.23 Å2
Buried surface area: 947.23 Å2
Dissociation area: 77.3 Å2
Dissociation energy (ΔGdiss): 11.58 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150714
Assembly 4
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Assembly Name: Cystic fibrosis transmembrane conductance regulator
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Multimeric state: monomeric
Accessible surface area: 12527.46 Å2
Buried surface area: 775.25 Å2
Dissociation area: 78.92 Å2
Dissociation energy (ΔGdiss): 11.64 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150714
Assembly 5
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Assembly Name: Cystic fibrosis transmembrane conductance regulator
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Multimeric state: homo octamer
Accessible surface area: 81029.12 Å2
Buried surface area: 33134.77 Å2
Dissociation area: 3,887.97 Å2
Dissociation energy (ΔGdiss): 36.78 kcal/mol
Dissociation entropy (TΔSdiss): 16.78 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-150716
Assembly 6
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Assembly Name: Cystic fibrosis transmembrane conductance regulator
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Multimeric state: homo octamer
Accessible surface area: 89176.42 Å2
Buried surface area: 20853.94 Å2
Dissociation area: 6,983.76 Å2
Dissociation energy (ΔGdiss): 12.03 kcal/mol
Dissociation entropy (TΔSdiss): 98.08 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-150716

Macromolecules

Cystic fibrosis transmembrane conductance regulator
Chains: A, B, C, D
Length: 286 amino acids
Theoretical weight: 32.42 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26361 (Residues: 389-673; Coverage: 19%)
Gene names: Abcc7, Cftr
Pfam: ABC transporter
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: ABC transporter ATPase domain-like
Cystic fibrosis transmembrane conductance regulator in PDB entry 1r0z, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 1r0z, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 1r0z, assembly 1, top view.
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