PDBe 1r0e

X-ray diffraction
2.25Å resolution

Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Allard J, Nikolcheva T, Gong L, Wang J, Dunten P, Avnur Z, Waters R, Sun Q, Skinner B

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + [tau protein] = ADP + [tau protein] phosphate. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 43.6 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P49841 (Residues: 35-420; Coverage: 92%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 83.957Å b: 84.009Å c: 180.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.252
Expression system: Trichoplusia ni