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Crystal structure of Adenosine deaminase complexed with FR235380

Source organism: Bos taurus
Biochemical function: 2'-deoxyadenosine deaminase activity
Biological process: negative regulation of adenosine receptor signaling pathway
Cellular component: anchoring junction

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EC 3.5.4.4: Adenosine deaminase

Reaction catalysed:
2'-deoxyadenosine + H(2)O = 2'-deoxyinosine + NH(3)
Systematic name:
Adenosine aminohydrolase
Alternative Name(s):
  • Deoxyadenosine deaminase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00962
Domain description: Adenosine deaminase
Occurring in:
  1. Adenosine deaminase
The deposited structure of PDB entry 1qxl contains 1 copy of Pfam domain PF00962 (Adenosine deaminase) in Adenosine deaminase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006330
Domain description: Adenosine/adenine deaminase
Occurring in:
  1. Adenosine deaminase
IPR006650
Domain description: Adenosine/AMP deaminase active site
Occurring in:
  1. Adenosine deaminase
IPR001365
Domain description: Adenosine deaminase domain
Occurring in:
  1. Adenosine deaminase
IPR032466
Domain description: Metal-dependent hydrolase
Occurring in:
  1. Adenosine deaminase
IPR028893
Domain description: Adenosine deaminase
Occurring in:
  1. Adenosine deaminase

Structure domain

CATH CATH domain
3.20.20.140
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Metal-dependent hydrolases
Occurring in:
  1. Adenosine deaminase
The deposited structure of PDB entry 1qxl contains 1 copy of CATH domain 3.20.20.140 (TIM Barrel) in Adenosine deaminase. Showing 1 copy in chain A.
SCOP SCOP annotation
51557
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Occurring in:
  1. Adenosine deaminase
The deposited structure of PDB entry 1qxl contains 1 copy of SCOP domain 51557 (Adenosine/AMP deaminase) in Adenosine deaminase. Showing 1 copy in chain A.

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