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CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1

Source organism: Homo sapiens
Biochemical function: insulin receptor binding
Biological process: insulin receptor signaling pathway
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02174
Domain description: PTB domain (IRS-1 type)
Occurring in:
  1. Insulin receptor substrate 1
The deposited structure of PDB entry 1qqg contains 2 copies of Pfam domain PF02174 (PTB domain (IRS-1 type)) in Insulin receptor substrate 1. Showing 1 copy in chain B.

PF00169
Domain description: PH domain
Occurring in:
  1. Insulin receptor substrate 1
The deposited structure of PDB entry 1qqg contains 2 copies of Pfam domain PF00169 (PH domain) in Insulin receptor substrate 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002404
Domain description: IRS-type PTB domain
Occurring in:
  1. Insulin receptor substrate 1
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Insulin receptor substrate 1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Insulin receptor substrate 1
IPR039011
Domain description: Insulin receptor substrate
Occurring in:
  1. Insulin receptor substrate 1

Structure domain

CATH CATH domain
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Insulin receptor substrate 1
The deposited structure of PDB entry 1qqg contains 4 copies of CATH domain 2.30.29.30 (PH-domain like) in Insulin receptor substrate 1. Showing 2 copies in chain B.
SCOP SCOP annotation
50755
Class: All beta proteins
Fold: PH domain-like barrel
Superfamily: PH domain-like
Occurring in:
  1. Insulin receptor substrate 1
The deposited structure of PDB entry 1qqg contains 4 copies of SCOP domain 50755 (Phosphotyrosine-binding domain (PTB)) in Insulin receptor substrate 1. Showing 2 copies in chain B.

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