› 1qoi

X-ray diffraction
2Å resolution

U4/U6 snRNP-specific cyclophilin SnuCyp-20

Released:
DOI: 10.2210/pdb1qoi/pdb
PDB entry 1qoi coloured by chain, front view.
PDB entry 1qoi coloured by chain, side view.
PDB entry 1qoi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin.
Reidt U, Reuter K, Achsel T, Ingelfinger D, Lührmann R, Ficner R
J Biol Chem 275 7439-42 (2000)
PMID: 10713041

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128928 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase H Chain: A
Molecule details ›
Chain: A
Length: 177 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43447 (Residues: 1-177; Coverage: 100%)
Gene names: CYP20, CYPH, PPIH
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 47.3Å b: 59.9Å c: 60.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Spliceosomal UsnRNP biogenesis, structure and function.
Will et al. (2001)
5 more

2 mentions without citation

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
Davis et al. (2010)
1 more