PDBe 1qng

X-ray diffraction
2.1Å resolution

Plasmodium falciparum Cyclophilin complexed with Cyclosporin A


Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Molecule details ›
Chain: D
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Peptidyl-prolyl cis-trans isomerase Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 18.85 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q25756 (Residues: 2-171; Coverage: 99%)
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P1
Unit cell:
a: 35.46Å b: 37.69Å c: 37.99Å
α: 61.08° β: 62.7° γ: 85.08°
R R work R free
0.15 0.15 0.19
Expression system: Escherichia coli BL21(DE3)