› 1qmt

X-ray diffraction
2.4Å resolution

Recombinant Human Eosinophil Cationic Protein

Released:
DOI: 10.2210/pdb1qmt/pdb
PDB entry 1qmt coloured by chain, front view.
PDB entry 1qmt coloured by chain, side view.
PDB entry 1qmt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of eosinophil cationic protein at 2.4 A resolution.
Boix E, Leonidas DD, Nikolovski Z, Nogués MV, Cuchillo CM, Acharya KR
Biochemistry 38 16794-801 (1999)
PMID: 10606511

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146304 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eosinophil cationic protein Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12724 (Residues: 28-160; Coverage: 100%)
Gene names: ECP, RNASE3, RNS3
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P63
Unit cell:
a: 100.159Å b: 100.159Å c: 31.281Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.176 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence.
Boix et al. (2007)
6 more

13 mentions without citation

Eosinophil granule proteins: form and function.
Acharya et al. (2014)
12 more