1qjj

X-ray diffraction
1.86Å resolution

Structure of astacin with a hydroxamic acid inhibitor

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139645 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Astacin Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 22.62 KDa
Source organism: Astacus astacus
UniProt:
  • Canonical: P07584 (Residues: 50-249; Coverage: 85%)
Sequence domains: Astacin (Peptidase family M12A)
Structure domains: Collagenase (Catalytic Domain)
PRO-LEU-GLY-HYDROXAMIC ACID Chain: B
Molecule details ›
Chain: B
Length: 4 amino acids
Theoretical weight: 300 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P3121
Unit cell:
a: 61.9Å b: 61.9Å c: 98.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.161 0.161 not available
Expression system: Not provided