PDBe 1qh5

X-ray diffraction
1.45Å resolution

HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE

Released:

Function and Biology Details

Reaction catalysed:
S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate. 
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydroxyacylglutathione hydrolase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 28.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16775 (Residues: 49-308; Coverage: 84%)
Gene names: GLO2, HAGH, HAGH1
Sequence domains:
Structure domains: Metallo-beta-lactamase, chain A

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 39.55Å b: 73.8Å c: 164.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.232
Expression system: Escherichia coli