PDBe 1q4x

X-ray diffraction
2.8Å resolution

Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 28.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P10828 (Residues: 209-461; Coverage: 55%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P6522
Unit cell:
a: 56.57Å b: 56.57Å c: 390.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.216 0.264
Expression system: Escherichia coli BL21