EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Systematic name:
DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase
Alternative Name(s):
- AP endonuclease class I
- AP lyase
- AP site-DNA 5'-phosphomonoester-lyase
- Deoxyribonuclease (apurinic or apyrimidinic)
- E. coli endonuclease III
- E.coli endonuclease III
- Endodeoxyribonuclease (apurinic or apyrimidinic)
- Micrococcus luteus UV endonuclease
- Phage-T(4) UV endonuclease
- Phage-T4 UV endonuclease
- X-ray endonuclease III
GO terms
Biochemical function:
- class I DNA-(apurinic or apyrimidinic site) endonuclease activity
- metal ion binding
- DNA N-glycosylase activity
- lyase activity
- hydrolase activity, hydrolyzing N-glycosyl compounds
- hydrolase activity, acting on glycosyl bonds
- hydrolase activity
- zinc ion binding
- DNA-(apurinic or apyrimidinic site) endonuclease activity
- catalytic activity
- damaged DNA binding
- DNA binding
- nucleic acid binding
- oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
1.10.8.50
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helicase, Ruva Protein; domain 3
Homology:
Helicase, Ruva Protein; domain 3
Occurring in:
SCOP annotations
81627
Class:
Small proteins
Fold:
Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:
Glucocorticoid receptor-like (DNA-binding domain)
Occurring in:
81626
Class:
All alpha proteins
Fold:
S13-like H2TH domain
Superfamily:
S13-like H2TH domain
Occurring in:
81623
Class:
All beta proteins
Fold:
N-terminal domain of MutM-like DNA repair proteins
Superfamily:
N-terminal domain of MutM-like DNA repair proteins
Occurring in: